Anne Li 6/17/17 For more information please email: firstname.lastname@example.org
A new rational drug design technique that uses a powerful computer algorithm to identify molecules that target different receptor sites on key cellular proteins could provide a new weapon in the battle against antibiotic resistance, potentially tipping the odds against the bugs. The technique, which has been validated against a drug-resistant bacterial strain, identifies compounds that target two or more receptor sites on proteins that inhibit a key cellular function. To obtain resistance to drug compounds developed with the technique, the microbes would have to simultaneously develop mutations in all the receptor pockets targeted by the drug — a challenge much more significant than developing resistance in a single receptor site.
See original article at: https://www.sciencedaily.com/releases/2017/06/170614142901.htm